Recurrent pregnancy loss is defined as the occurrence of three or more consecutive pregnancy losses. In clinical terms, a pregnancy loss occurs when a pregnancy ends involuntarily before the 20th week. Ultrasound has confirmed the pregnancy or pregnancy tissue has been identified after a loss has been identified.
Genetic abnormalities, or chromosomal abnormalities, are primarily responsible for most pregnancy losses. An abnormality can occur in the egg, sperm, or early embryo. At least 30-60% of all conceptions end within the first 12 weeks of gestation; however, 12-15% of all clinically recognized pregnancies end in miscarriage. Up to 50% of the time, the woman is unaware that she was pregnant. The risk of miscarriage increases with previous pregnancy losses, but it is typically less than 50%.
Treatment recommendations for patients with recurrent pregnancy loss are based on the underlying cause of the loss.